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Vacodil must not be used in patients with hypersensitivity to carvedilol or any component of the product; unstable/decompensate heart failure; clinically manifest liver dysfunction.
As with other beta-blockers, Vacodil must not be used in patients with: 2nd and 3rd degree AV block (unless a permanent pacemaker is in place); Severe bradycardia (<50 bpm); Sick sinus syndrome (including sino-atrial block); Severe hypotension (systolic blood pressure <85 mmHg); Cardiogenic shock; History of bronchospasm or asthma.
