Vacodil Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Carvedilol

Indications/Uses

Management of essential HTN. Angina pectoris. Symptomatic chronic heart failure.

Click to view Vacodil detailed prescribing information

Dosage/Direction for Use

Essential HTN Initially 12.5 mg once daily for 1st 2 days, then 25 mg once daily thereafter. May be increased subsequently at intervals of at least 2 wk up to max: 50 mg once or bd. Angina pectoris Initially 12.5 mg bd for 1st 2 days, then 25 mg bd. Thereafter, may be increased at intervals of at least 2 wk up to max: 100 mg bd. Symptomatic, stable, chronic heart failure Initially 3.125 mg bd for 2 wk, may be increased at intervals not <2 wk to 6.25 mg, 12.5 mg & 25 mg bd. Mild, moderate to severe chronic heart failure patient <85 kg Max: 25 mg bd, >85 kg Max: 50 mg bd.

Click to view Vacodil detailed prescribing information

Overdosage

View Vacodil overdosage for action to be taken in the event of an overdose.

Administration

Should be taken with food.

Contraindications

Hypersensitivity. Unstable/decompensated heart failure. 2nd & 3rd degree AV block, severe bradycardia (<50 bpm), sick sinus syndrome ie, SA block, severe hypotension (systolic BP <85 mmHg), cardiogenic shock, history of bronchospasm or asthma. Hepatic dysfunction.

Click to view Vacodil detailed prescribing information

Special Precautions

Hypersensitivity. Transient worsening of heart failure or fluid retention. Low BP (systolic BP <100 mmHg), ischemic heart disease, diffuse vascular disease, COPD, bronchospasm, DM, peripheral vascular disease, Raynaud's phenomenon, thyrotoxicosis, bradycardia, psoriasis, pheochromocytoma. Prinzmetal's variant angina. Patients undergoing general surgery. Contact lens wearers. Avoid abrupt w/drawal. Combination w/ digitalis glycosides. Concomitant use w/ verapamil- or diltiazem-type Ca-channel blockers, other antiarrhythmics, anesth. May affect ability to drive or operate machinery. Underlying renal insufficiency. Pregnancy. Not recommended during lactation. Childn <18 yr.

Click to view Vacodil detailed prescribing information

Use In Pregnancy & Lactation

Click to view Vacodil detailed prescribing information

Adverse Reactions

Dizziness, headache, asthenia, fatigue. Bradycardia, postural hypotension, hypotension, edema; nausea, diarrhea, vomiting, abdominal pain; increased wt, hypercholesterolemia, hyper- & hypoglycemia, worsening of BP control; vision abnormalities, reduced lacrimation, eye irritation; asthma, dyspnea; pain in extremities.

Click to view Vacodil detailed prescribing information

Drug Interactions

Increased digoxin conc. Enhanced blood sugar-reducing effect of insulin or oral hypoglycemics. Reduced plasma conc by rifampicin. Increased AUC by cimetidine. Signs of hypotension &/or severe bradycardia w/ catecholamine-depleting agents eg, reserpine and MAOIs. Increased mean trough cyclosporine conc. Increased risk of AV conduction disturbances w/ verapamil- & diltiazem-type Ca-channel blockers or other antiarrhythmics. Potentiated BP- & heart rate-lowering effects w/ clonidine. Potentiated effect of other antihypertensives eg, α₁-receptor antagonist. Synergistic -ve inotropic & hypotensive effects w/ anesth. Intensified BP-lowering effect w/ barbiturates, phenothiazines, TCAs, vasodilating drugs, alcohol.

Click to view Vacodil detailed prescribing information

Storage

View Vacodil storage conditions for details to ensure optimal shelf-life.

Description

View Vacodil description for details of the chemical structure and excipients (inactive components).

Action

View Vacodil mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Beta-Blockers

ATC Classification

C07AG02 - carvedilol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Vacodil FC tab 25 mg

Packing/Price

10 × 10's;3 × 10's

Form

Vacodil FC tab 6.25 mg

Packing/Price

10 × 10's;3 × 10's

Vacodil

carvedilol

Manufacturer:

Aurobindo Pharma

Distributor:

Unimed