Twinrix Drug Interactions

No data on concomitant administration of Twinrix with specific hepatitis A immunoglobulin or hepatitis B immunoglobulin have been generated. However, when the monovalent hepatitis A and hepatitis B vaccines were administered concomitantly with specific immunoglobulins, no influence on seroconversion was observed although it may result in lower antibody titres.
Clinical studies have demonstrated that Twinrix can be administered concomitantly with either diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, Haemophilus influenzae type b (DTPa-IPV/Hib) or Measles-Mumps-Rubella vaccines in the second year of life. In these trials, the injectable vaccines were given at different injection sites.
Although the concomitant administration of Twinrix and other vaccines has not specifically been studied, it is anticipated that, if different syringes and other injection sites are used, no interaction will be observed.
It may be expected that in patients receiving immunosuppressive treatment or patients with immunodeficiency, an adequate response may not be achieved.