Twinrix

Twinrix

vaccine, hepatitis a + hepatitis b

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 1 mL Inactivated HAV 720 ELISA U adsorbed, recombinant HBsAg 20 mcg adsorbed
Indications/Uses
Non-immune adults, adolescents & childn from 1 yr at risk of both hepatitis A & B infection.
Dosage/Direction for Use
IM Adult & adolescent ≥16 yr 3 primary doses at 0, 1, 6 mth (standard schedule) or 0, 7, 21 days followed by 4th dose at 12 mth (rapid schedule). Childn & adolescent 1-15 yr 2 primary doses at 0, 6-12 mth. Booster dose General guidelines can be drawn from experience w/ monovalent vaccines.
Contraindications
Hypersensitivity to vaccine, neomycin or after previous inj.
Special Precautions
Anaphylactic reactions. Not to be inj intravascularly. Not for prevention against infection caused by other agents eg, hepatitis C, E & other pathogens infecting the liver. Not recommended for post-exposure prophylaxis (eg, needle-stick injury). Postpone vaccination in patients w/ acute severe febrile illness. Syncope. Haemodialysis or immunocompromised patients. Pregnancy & lactation.
Adverse Reactions
Headache; inj site pain & redness, fatigue. GI symptoms eg, diarrhoea, nausea, vomiting; inj site swelling. Adult & childn ≥16 yr: Inj site reaction, malaise. Childn 1-15 yr: Loss of appetite; irritability. Drowsiness; fever.
Drug Interactions
Adequate response may not be achieved w/ immunosuppressants.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07BC20 - combinations ; Belongs to the class of hepatitis viral vaccines.
Presentation/Packing
Form
Twinrix vaccine (inj) (pre-filled syringe) 1 mL
Packing/Price
1's
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