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There have been post-marketing reports of overdose with piperacillin and tazobactam. The majority of those events experienced including nausea, vomiting, and diarrhea have also been reported with the usual recommended dosages. Patients may experience neuromuscular excitability or convulsions if higher than recommended doses are given intravenously (particularly in the presence of renal failure).
Treatment should be supportive and symptomatic according to the patient's clinical presentation. Excessive serum concentrations of either piperacillin-tazobactam may be reduced by haemodialysis. In case of severe, anaphylactic reactions, the usual counter measures are to be initiated.
