Adult & childn ≥12 yr, <50 kg on haemodialysis 4.5 g every 8 hr. Total daily dose: 2.5-4.5 g every 6-8 hr.
Neutropenia Adult & childn ≥12 yr, >50 kg 4.5 g every 6 hr in combination w/ aminoglycoside,
<50 kg 90 mg/kg every 6 hr in combination w/ aminoglycoside.
Intra-abdominal infection Childn 2-12 yr, up to 40 kg 112.5 mg/kg every 8 hr,
>40 kg Adult dose.
Adult & childn >50 kg CrCl 20-80 mL/min Piperacillin 12 g/tazobactam 1.5 g daily every 8 hr in divided doses,
<20 mL/min Piperacillin 8 g/tazobactam 1 g every 12 hr in divided doses.
Childn <50 kg CrCl 40-80 mL/min Piperacillin 80 mg/tazobactam 10 mg every 6 hr,
20-40 mL/min Piperacillin 80 mg/tazobactam 10 mg every 8 hr,
<20 mL/min Piperacillin 80 mg/tazobactam 10 mg every 12 hr.
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