Tazpen Adverse Reactions

Adverse reactions are listed in frequency categories as follows: Very Common ≥10%, Common ≥1%, Uncommon ≥0.1% and <1%, Rare ≥0.01% and <0.1%, Very rare <0.01%.
Infections and infestations: Uncommon: Candidal superinfection.
Blood and lymphatic system: Uncommon: Leukopenia, neutropenia, thrombocytopenia.
Rare: Anemia, bleeding manifestations (including purpura, epistaxis, bleeding time prolonged), eosinophilia, haemolytic anemia.
Very rare: Agranulocytosis, Coombs direct test positive, pancytopenia, prolonged partial thromboplastin time, prothrombin time prolonged, thrombocytosis.
Immune system disorders: Uncommon: Hypersensitivity reaction.
Rare: Anaphylactic/anaphylactoid reaction (including shock).
Metabolism and nutrition disorders: Very rare: Blood albumin decreased, blood glucose decreased, blood total protein decreased, hypokalemia.
Nervous system disorders: Uncommon: Headache, insomnia.
Vascular disorders: Uncommon: Hypotension, phlebitis, thrombophlebitis.
Rare: Flushing.
Gastrointestinal: Common: Diarrhea, nausea, vomiting.
Uncommon: Constipation, dyspepsia, jaundice, stomatitis.
Rare: Abdominal pain, pseudomembranous colitis.
Hepatobiliary: Uncommon: Alanine aminotransferase increased, aspartate aminotransferase increased.
Rare: Bilirubin increased, blood alkaline phosphatase increased, gamma-glutamyltransferase increased, hepatitis.
Skin and subcutaneous tissue disorders: Common: Rash.
Uncommon: Pruritis, urticaria.
Rare: Bullous dermatitis, erythema multiforme.
Very Rare: Stevens-Johnson Syndrome, toxic epidermal necrolysis.
Musculoskeletal, connective tissue and bone disorders: Rare: Arthralgia.
Renal and urinary disorders: Uncommon: Blood creatinine increased.
Rare: Interstitial nephritis, renal failure.
Very rare: Blood urea nitrogen increased.
General disorders and administration site conditions: Uncommon: Fever, injection site reaction.
Rare: Rigors.
Piperacillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.