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Symptoms and treatment for overdosage and antidotes: Studies have indicated that the body can apparently handle doses up to 4 g without saturating any of its eliminating mechanism. One patient who ingested 25 g of naproxen experienced mild nausea and indigestion. Drowsiness, heartburn or vomiting may also occur following overdosage of the drug. One death due to CNS depression has been attributed to naproxen overdosage.
In acute overdosage, the stomach should be emptied immediately by inducing emesis or by gastric lavage. If the patient is comatose, having seizures or lacks the gag reflex, gastric lavage may be performed if an endotracheal tube with cuff inflated is in place to prevent aspiration of gastric contents. Supportive and symptomatic treatment should be initiated. Animal studies indicate that prompt administration of activated charcoal will reduce absorption of the drug. Haemodialysis appears to be of no value in enhancing elimination of naproxen.
