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Contraindicated in patients with active peptic ulceration. This drug is contraindicated in patients who have had allergic reactions to naproxen sodium. It is also contraindicated in patients in whom aspirin or other NSAID induce the syndrome of asthma, rhinitis and nasal polyps. Both types of reactions have the potential of being fatal.
Therefore, careful questioning of patients for such things as asthma, nasal polyps, urticaria and hypotension associated with nonsteroidal anti-inflammatory drugs before starting therapy is important. In addition, if such symptoms occur during therapy, treatment should be discontinued.
Anaphylactoid reactions to naproxen sodium whether of true allergic type or the pharmacologic idiosyncratic type, usually but not always occur in patients with a known history of such reactions.
