Rheumatic disorder Initially 275 mg bd, may be increased to 1,100 mg daily in 2 divided doses. Acute gout Initially 825 mg followed by 275 mg 8 hrly. Dysmenorrhoea Initially 550 mg followed by 275 mg 6-8 hrly if needed. Max daily dose: Not ≥1,375 g.
Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity; if abnormal liver test persist or worsen, if clinical signs & symptoms consistent w/ liver disease develops or systemic manifestation occurs. Serious cutaneous adverse events eg, exfoliative dermatitis, TEN & SJS. Patients w/ prior history of GI disease; other risk factors associated w/ PUD eg, alcoholism, smoking, corticosteroid therapy; CV thrombotic events eg, MI; HTN, fluid retention or heart failure. Monitor BP during treatment & at regular intervals thereafter; liver function during therapy. Not to be coadministered w/ other NSAIDs. Concomitant use w/ antihypertensives; diuretics. High-dose & long-term use. Renal impairment, chronic alcoholic liver disease, cirrhosis. Hepatic impairment. Not to be used during late pregnancy. Not recommended in childn <16 yr. Elderly, debilitated patients. FC tab 550 mg: Na-restricted diet.
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