Stacytine Special Precautions

Bronchospasms may occur with the use of acetylcysteine. If bronchospasm occurs, the medicinal product should be discontinued immediately.
Bronchial secretions may become more fluid and increase in volume, in particular at the start of the treatment with acetylcysteine. When a patient is unable to cough up the secretions effectively, postural drainage and bronchoaspiration should be performed.
Caution is advised in patients with a history of peptic ulcer, especially when used concomitantly with other medicinal products known to irritate the mucous membrane of the gastrointestinal tract.
Serious skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported whilst taking acetylcysteine, but these occur rarely. For this reason, medical advice should be sought immediately, and the patient should stop taking acetylcysteine in the event of new-onset changes to the skin and mucous membranes.
There are no studies on the efficacy and safety of acetylcysteine 600 mg effervescent tablet in adolescent population. However, mild, moderate or severe adverse reactions have been reported with the use of IV acetylcysteine in adolescents' population.
This product should be used with caution by patients with histamine intolerance. They should avoid long-term therapy because acetylcysteine effervescent tablet affects the metabolism of histamine and can lead to symptoms of intolerance (e.g. headaches, rhinitis, itching).
No specific studies have been performed in patients with renal or hepatic impairment. Hepatic and renal impairment reduce clearance and increase acetylcysteine plasma levels which may result in an increase in adverse drug reactions due to drug accumulation.
Stacytine Effervescent Tablet contains sodium. Caution is advised in patients on a sodium-restricted diet.
Stacytine Effervescent Tablet contains aspartame, which is a source of phenylalanine. This medicine is not suitable for phenylketonurics.
A mild sulfur odour does not indicate a change in the medicinal product but is a property of the active substance itself.
Effects on ability to drive and use machines: There are no data on the effect of acetylcysteine on the ability to drive. An effect is, however, not likely.