Sign Out
The action of non-depolarising muscle relaxants is markedly potentiated with sevoflurane, therefore, when administered with sevoflurane, dosage adjustments of these agents should be made.
Sevoflurane is similar to isoflurane in the sensitisation of the myocardium to the arrhythmogonic effect of exogenously administered adrenaline.
MAC values for Sevoflurane decrease with the addition of nitrous oxide as indicated in the table on 'Effect of Age on MAC of Sevoflurane' (see Dosage & Administration).
As with other agents, lesser concentrations of sevoflurane may be required following use of an intravenous anaesthetic e.g. propofol. The metabolism of Sevoflurane may be increased by known inducers of CYP2E1 (e.g. isoniazid and alcohol), but it is not inducible by barbiturates.
