Sojourn Adverse Reactions

Most adverse events are mild to moderate in severity and transient. Nausea and vomiting are commonly observed in the post-operative period at a similar incidence to those found in other inhalation anaesthetics. In addition to nausea and vomiting, other frequent adverse events were: in adults, hypotension; in elderly, hypotension and bradycardia; in children, agitation and increased cough.
Less frequent adverse events associated with sevoflurane administration were; agitation, somnolence, chills, bradycardia, dizziness, increased salivation, respiratory disorder, hypertension, tachycardia, laryngismus, fever, headache, hypothermia, increased SGOT.
Occasionally reported adverse effects associated with the administration of sevoflurane administration include: arrhythmias, increased LDH, increased SGPT, hypoxia, apnoea, leukocytosis, ventricular extrasystoles, supraventricular extrasystoles, asthma, confusion, increased creatinine, urinary retention, glycosuria, atrial fibrillation, complete AV block, bigeminy, leucopenia. Allergic reactions, such as rash, urticaria, pruritus, bronchospasm, anaphylactic or anaphylactoid reactions have also been reported. As with all potent inhaled anaesthetics, sevoflurane may cause dose-dependent cardiorespiratory depression.
Convulsions may occur extremely rarely following sevoflurane administration, particularly in children. There have been very rare reports of pulmonary oedema.