Sinu-C Overdosage

In case of overdose call the National Poison Centre at 1800-888-099.
Paracetamol: Symptoms: Symptoms of Paracetamol overdosage in the first 24 hours are diarrhoea, sweating, loss of appetite, nausea or vomiting, stomach cramps or pain. Persistence beyond this time, pain, swelling or tenderness in the upper abdomen or stomach area, usually indicates development of hepatic necrosis. Liver damage may be apparent within 12 to 48 hours after overdosage.
Treatment: Despite a lack of significant early symptoms, patients who have taken an overdose of Paracetamol should be admitted to hospital immediately.
1. Induction of vomiting may reduce absorption if 100 to 150 mg/kg or greater of Paracetamol is ingested.
2. Administration of activated charcoal should be considered if Paracetamol in excess of 150 mg/kg or 12 g whichever is smaller, is thought to have been ingested within the previous hour.
3. Gastric lavage is indicated if the patient is unwilling or unable to take the activated charcoal.
4. Dextrose and blood infusion.
5. Antidotes such as acetylcysteine and methionine protect the liver if given within 10 to 12 hours of ingestion and other supportive treatments may be provided in the hospital.
6. Haemoperfusion may be worthwhile if too much time has elapsed since the poisoning to allow the use of antidote.
Pseudoephedrine HCl: Symptoms: Overdosage of Pseudoephedrine closely resembles those resulting from overdosage of any sympathomimetics. These symptoms include nausea, vomiting, irritability, nervousness, convulsion, tachycardia, spasms and respiratory failure. Hypertension may develop initially, followed later by hypotension accompanied by anuria.
Treatment: For acute overdosage, the drug should be discontinued and supportive and symptomatic treatment instituted. If respirations are shallow or cyanosis is present, assisted respiration is recommended. Convulsion may be controlled with Diazepam. In the presence of cardiovascular collapse, blood pressure should be maintained. Hypertension may be managed with α-adrenergic blocker and tachycardia may be controlled with b-adrenergic blocker. Catheterisation of the bladder may be necessary.
Chlorpheniramine Maleate: Symptoms: Overdosage of antihistamine include extreme sleepiness, confusion, weakness, blurred vision, large pupils, dry mouth, flushing, shaking, insomnia, hallucinations and possibly seizures.
Treatment: Treatment of acute antihistamine overdosage consists of symptomatic and supportive therapy including artificial respiration, if necessary. If the patient is conscious, has not lost the gag reflex, and is not having seizures, emesis should be induced. If emesis cannot be induced, gastric lavage and administration of activated charcoal are indicated.