Sinu-C Drug Interactions

Cautions should be taken when Paracetamol, Pseudoephedrine and Chlorpheniramine are administered concurrently with these medications: Paracetamol may increase Chloramphenicol concentrations.
Prolonged use or high doses of Paracetamol may increase the effects of oral anticoagulants (e.g. Warfarin).
Paracetamol absorption is increased by drugs that increase gastric emptying (e.g. Metoclopramide).
Paracetamol absorption is decreased by drugs which decrease gastric emptying (e.g. Propantheline or narcotic analgesics, Pethidine).
Paracetamol toxicity may be increased by the concomitant use of enzyme-inducing agents (e.g. alcohol or Phenytoin).
The absorption of Pseudoephedrine is increased by concomitant use of Aluminium Hydroxide mixture (e.g. antacids) and decreased by the administration of Kaolin.
The concurrent use of Pseudoephedrine may reduce the hypotensive effect of certain adrenergic neurone blockers (e.g. Bretylium).
The sedative effect of Chlorpheniramine may be potentiated when used with alcohol, barbiturates, anxiolytics, tricyclic antidepressants (TCAs), hypnotics or other CNS depressants.
The antimuscarinic effects of Chlorpheniramine may be increased by the concomitant use with other antimuscarinic drugs.