Renson Mechanism of Action

Pharmacology: Pharmacodynamics: Hydrocortisone or cortisol is a natural glucocorticoid (corticosteroid hormone). It acts by binding to steroid receptors in the cytoplasm. It acts mainly by reducing the local inflammation reaction. It alleviates inflammation symptoms and eliminates allergic symptoms.
Pharmacokinetics: Hydrocortisone is absorbed rapidly and completely from the alimentary tract. Because of first-pass metabolism, its bioavailability varies between 25% and 90%. In plasma, the peak concentration of hydrocortisone is reached in 1-2 hours after dosing. It is bound to plasma transcortin and albumin. At low concentrations, 10% of hydrocortisone is free; at higher concentrations, the binding capacity of transcortin is saturated and the proportion of free drug can increase to 40-50%. Its volume of distribution is 0.4-0.7 l/kg. The pharmacological half-life of hydrocortisone averages 1.5 hours, but the half-life of biological effect is considerably longer, approx. 10 hours. Hydrocortisone penetrates the placenta and is excreted in small amounts in breast milk. The elimination of hydrocortisone may be prolonged in liver diseases and shortened in thyrotoxicosis.