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Pharmacology: Pharmacodynamics: In clinical studies Priorix has been demonstrated to be highly immunogenic. Antibodies against measles were detected in 98.0%, against mumps in 96.1% and against rubella in 99.3% of previously seronegative vaccinees.
In comparative studies, antibodies against measles, mumps and rubella were detected in 98.7%, 95.5% and 99.5% of previously seronegative vaccinees who received Priorix compared to 96.9%, 96.9% and 99.5% in the group receiving a commercially available measles, mumps and rubella combined vaccine.
Subjects followed up to 12 months following vaccination all remained seropositive for anti-measles and anti-rubella antibodies. 88.4% were still seropositive at month 12 for anti-mumps antibody. This percentage is in line with what was observed for the commercially available measles, mumps and rubella combined vaccine (87%).
Clinical Studies: See Pharmacology: Pharmacodynamics previously mentioned.
Pharmacokinetics: Not relevant for vaccines.
