Priorix Drug Interactions

If tuberculin testing has to be done it should be carried out before or simultaneously with vaccination since it has been reported that live measles (and possibly mumps) vaccine may cause a temporary depression of tuberculin skin sensitivity. This anergy may last for 4-6 weeks and tuberculin testing should not be performed within that period after vaccination to avoid false negative results.
Clinical studies have demonstrated that Priorix can be given simultaneously with any of the following monovalent or combination vaccines: hexavalent vaccine (DTPa-HBV-IPV/Hib), diphtheria-tetanus-acellular pertussis vaccine (DTPa), reduced antigen diphtheria-tetanus-acellular pertussis vaccine (dTpa), Haemophilus influenzae type b vaccine (Hib), inactivated polio vaccine (IPV), hepatitis B vaccine (HBV), hepatitis A vaccine (HAV), meningococcal serogroup B vaccine (MenB), meningococcal serogroup C conjugate vaccine (MenC), meningococcal serogroups A, C, W-135 and Y conjugate vaccine (MenACWY), varicella vaccine and pneumococcal conjugate vaccine (PCV).
In addition, it is generally accepted that combined measles, mumps and rubella vaccine may be given at the same time as the oral polio vaccine (OPV) or the diphtheria-tetanus-whole cell pertussis vaccine (DTPw).
If Priorix is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.
If Priorix cannot be given at the same time as other live attenuated vaccines, an interval of at least one month should be left between both vaccinations.
In subjects who have received human gammaglobulins or a blood transfusion, vaccination should be delayed for at least three months because of the likelihood of vaccine failure due to passively acquired mumps, measles and rubella antibodies.
Priorix may be given as a booster dose in subjects who have previously been vaccinated with another measles, mumps and rubella combined vaccine.