Parecoxb Description

PARECOXB parecoxib (as sodium) 40 mg powder for solution for injection.
Chemical name: N-[[4-(5-methyl-3-phenyl-4 isoxazolyl) phenyl]sulfonyl] propanamide, sodium salt.
Molecular formula: C₁₉H₁₇N₂O₄SNa.
Molecular weight: 392.41.
CAS number 198470-85-8.
Parecoxib sodium is a white to off-white solid that is very soluble in water. The formulated drug product is soluble in normal (0.9%) saline at >50 mg/mL.
Powder for Injection and Powder and Diluent for Injection: PARECOXB Injection is a white to off-white, preservative-free, lyophilised powder in a single-use vial. For intravenous (IV) or intramuscular (IM) administration, PARECOXB Injection should be reconstituted with 2 mL sodium chloride solution (0.9% w/v), or a suitable alternative (see DOSAGE & ADMINISTRATION).
Reconstituted Solution: The reconstituted solution is clear and colourless.
PARECOXB Injection 40 mg contains parecoxib sodium, sodium phosphate-dibasic anhydrous; phosphoric acid and/or sodium hydroxide may have been added to adjust pH.
When reconstituted in sodium chloride solution (0.9% w/v), PARECOXB Injection contains approximately 0.44 mEq of sodium per 40 mg vial.