Hypersensitivity to sulfonamides. Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. History of GI disease eg, ulceration, bleeding, perforation; risk factors associated w/ PUD. Increased risk of CV & thrombotic adverse events in long-term use. Patients w/ compromised cardiac function, pre-existing oedema or other conditions predisposed to or worsened by fluid retention, or at risk of hypovolemia; significant risk factors for CV events eg, HTN, hyperlipidaemia, DM, smoking. May mask fever & other signs of inflammation. Closely monitor BP during therapy. Ensure adequate hydration. Avoid use w/ other non-ASA NSAIDs. Concomitant use w/ warfarin or other oral anticoagulants, glucocorticoids, SSRIs, other antiplatelets & NSAIDs, alcohol, ASA, fluconazole, corticosteroid therapy, diuretics. May affect ability to drive & use machines. Not recommended in severe hepatic impairment. Moderate hepatic (Child-Pugh 7-9) & severe renal (CrCl <30 mL/min) impairment. Not recommended in women of childbearing potential. Not to be given during pregnancy. Lactation. Childn <18 yr. Elderly or debilitated patients.
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