Pantaz Dosage/Direction for Use

The following information applies unless pantoprazole has been otherwise prescribed by the doctor.
Follow these instructions, as otherwise pantoprazole may not have the desired effect.
Adults and adolescents 12 years of age and above: Treatment of moderate and severe reflux oesophagitis: One tablet of pantoprazole 40mg per day. In individual cases the dose may be doubled (increase to 2 tablets pantoprazole 40mg daily) especially when there has been no response to other treatment.
Adults: Eradication of H. pylori in combination with two appropriate antibiotics: In cases of duodenal or gastric ulcer in which infection with Helicobacter pylori has been confirmed, the microorganism should be eradicated by combination treatment. Depending on the resistance pattern, the following combinations are recommended: a) 2 x 1 Controloc 40 mg gastro-resistant tablet/day: + 2 x 1000 mg amoxicillin/day; + 2 x 500 mg clarithromycin/day.
b) 2 x 1 Controloc 40 mg gastro-resistant tablet/day: + 2 x 500 mg metronidazole/day; + 2 x 500 mg clarithromycin/day.
c) 2 x 1 Controloc 40 mg gastro-resistant tablet/day: + 2 x 1000 mg amoxicillin/day; + 2 x 500 mg metronidazole/day.
Treatment of gastric and duodenal ulcer: One tablet of pantoprazole 40mg per day. In individual cases the dose may be doubled (increase to 2 tablets pantoprazole 40mg daily) especially when there has been no response to other treatment.
Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions: For the long-term management of Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions patients should start their treatment with a daily dose of 80 mg (2 tablets of pantoprazole tablets 40 mg). Thereafter, the dosage can be titrated up or down as needed using measurements of gastric acid secretion to guide. With doses above 80 mg daily, the dose should be divided and given twice daily. A temporary increase of the dosage above 160 mg pantoprazole is possible but should not be applied longer than required for adequate acid control. Treatment duration in Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions is not limited and should be adapted according to clinical needs.
Children below 12 years of age: Pantoprazole 40mg is not recommended for use in children below 12 years of age due to limited data in this age group.
Type and duration of treatment: Combination therapy for eradication of Helicobacter pylori infection usually lasts 7 days and can be extended to a maximum of 2 weeks. If after this time further treatment with Pantoprazole 40 mg is indicated to ensure that the ulcer heals completely, the dose recommendations for gastric and duodenal ulcers must be observed. In the majority of cases, a duodenal ulcer heals completely within 2 weeks. If a two-week treatment period is not sufficient, healing will be achieved in almost all cases within a further 2 weeks. Gastric ulcers and reflux esophagitis usually require a 4-week course of treatment. If this should be inadequate, healing will in most cases be achieved within a further 4 weeks. Treatment should not exceed 8 weeks as experience with long-term use is limited. Treatment duration in Zollinger-Ellison-Syndrome and other pathological hypersecretory conditions is not limited and should be adapted according to clinical needs.
Instructions for use/handling: Pantoprazole 40mg tablets must not be chewed or crushed and must be swallowed whole with water. In combination therapy for eradication of Helicobacter pylori infection the second pantoprazole 40mg tablet should be taken before the evening meal.
Special Patient Populations: Impaired hepatic function: A daily dose of 20 mg pantoprazole (1 tablet of 20 mg pantoprazole or half a vial of 40 mg pantoprazole I.V.) should not be exceeded in patients with severe liver impairment.
Impaired renal function: No dose adjustment is necessary in patients with impaired renal function.
Route of Administration: To be administered orally.