Adult & adolescent ≥12 yr Moderate & severe reflux esophagitis, gastric & duodenal ulcer 40 mg daily, may be increased to 2-tab 40 mg daily.
H pylori eradication in duodenal or gastric ulcers 40 mg bd + amoxicillin 1,000 mg bd + clarithromycin 500 mg bd, or 40 mg bd + metronidazole 500 mg bd + clarithromycin 500 mg bd or 40 mg bd + amoxicillin 1,000 mg bd + metronidazole 500 mg bd.
Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg daily, may be titrated up or down as needed. Duration of treatment:
H pylori eradication 7 days up to max: 2 wk.
Duodenal ulcer 2 wk.
Gastric ulcer & reflux esophagitis 4 wk up to max: 8 wk.
Severe hepatic impairment Not to exceed 20 mg daily.
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