Pamidol Mechanism of Action

Pharmacology: Pharmacodynamics: Iopamidol is contrast medium belonging to the new generation of non-ionic compounds, which are water water-soluble because its molecular structure incorporates Hydrophilic groups. This new class of contrast media differs significantly from other compounds used in other radiological procedures, all of which are soluble only when the radiopaque molecule is ionized by forming a salt with sodium and or meglumine. Such products have been shown to have good tolerability but due to its inherently high osmality this is responsible for a number of side effects that may occur after administration. Non-Ionic contrast agents have resulted in decrease in the general toxicity and improvement both in the local and tissue tolerability as well as by the more delicate structures of the human body as vascular endothelia and the central nervous system.
Iopamidol has been shown to be effective as an X-ray contrast medium in neuroradiology, angiography, venography, arthrography, urography, cerebral angiography and left ventriculography and coronary arteriography.
Pharmacokinetics: The pharmacokinetics of iopamidol conforms to an open two compartment pharmacokinetic model with first order elimination.
Distribution volume is equivalent to extracellular fluid.
Elimination is almost completely through the kidneys. Less than 1% of the administered dose have been recovered in the faeces up to 72 hours after dosing. Elimination is rapid; up to half the administered dose may be recovered in the urine in the first two hours of dosing.
There is no evidence of biotransformation.
Serum protein binding is negligible.