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If overdosage with latanoprost occurs, treatment should be symptomatic.
Apart from ocular irritation and conjunctival hyperemia, no other ocular adverse effects are known if latanoprost is overdosed.
If latanoprost is accidentally ingested the following information may be useful: One 2.5 mL bottle contains 125 micrograms latanoprost. More than 90% is metabolized during the first pass through the liver.
Intravenous infusion of 3 mcg/kg in healthy volunteers induced no symptoms, but a dose of 5.5-10 mcg/kg caused nausea, abdominal pain, dizziness, fatigue, hot flushes and sweating. In patients with moderate bronchial asthma, bronchoconstriction was not induced by latanoprost when applied topically on the eyes in a dose of seven times the clinical dose of latanoprost.
