Increased iris pigmentation; eyelid skin darkening; eyelash darkening, thickening & lengthening. Not recommended in patients w/ active & intraocular inflammation (iris/uveitis). Avoid use in active herpes simplex keratitis & in patients w/ history of recurrent herpetic keratitis specifically associated w/ prostaglandin analogues. Aphakic patients, pseudophakic patients w/ torn posterior lens cap, patients w/ known risk factors for macular edema; inflammatory neovascular glaucoma. History of herpetic keratitis. Potential for heterochromia in patients receiving unilateral treatment. Not recommended in concomitant use w/ other prostaglandins or prostaglandin analogues. Concomitant use w/ other ophth drugs lowering IOP. Administer 5 min apart if >1 topical ophth is used. Remove contact lens prior to & reinsert 15 min after instillation. May affect ability to drive & use machines. Pregnancy & lactation. Paed <1 yr & infants <36 wk gestation.
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