Hypersensitivity reactions have been reported in patients who have exhibited hypersensitivity to other selective 5HT3-receptor antagonists. Very rarely and predominantly with IV ondansetron, transient electrocardiogram (ECG) changes including QT interval prolongation have been reported.
As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration.
Effect on Ability to Drive and Use Machine: In psychomotor testing, ondansetron does not impair performance nor cause sedation.