CINV & RINV Adult 8 mg 1-2 hr prior to chemo- or RT, followed by 8 mg every 12 hr for max: 5 days.
Highly emetogenic chemotherapy Single dose up to 24 mg w/ oral dexamethasone Na phosphate 12 mg 1-2 hr prior to chemotherapy.
CINV Childn & adolescent 3-17 yr, >1.2 m2 5 mg/m
2 or 8 mg IV + 8 mg tab after 12 hr on day 1 then 8 mg tab every 12 hr on days 2-6,
≥0.6 to ≤1.2 m2 5 mg/m
2 IV + 4 mg tab after 12 hr on day 1 then 4 mg tab every 12 hr on days 2-6,
>10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hr on day 1 then 4 mg tab every 12 hr on days 2-6. Commence oral dosing 12 hr after IV dose, may be continued for up to 5 days. Total dose: Not to exceed 32 mg over 24 hr.
Adult PONV 16 mg 1 hr prior to anaesth.
Moderate or severe hepatic impairment Not to exceed 8 mg total daily dose.