Noxworm

Albendazole.

Active Ingredient: Chewable tab: Each tablet contains Albendazole 200 mg.
Oral susp: Each 10 ml contains Albendazole 400 mg.
Excipients/Inactive Ingredients: Oral susp: Preservatives: Methyl Hydroxybenzoate 0.2% w/v, Propyl Hydroxybenzoate 0.03% w/v, Sodium Benzoate 0.2% w/v.

Pharmacology: Albendazole a broad-spectrum anthelmintic that exhibits vermicidal, ovicidal and larvacidal activities. Albendazole exerts its anthelmintic effect by inhibiting tubulin polymerization. This causes a cascade of metabolic disruption which includes energy depletion, immobilization and finally death. The anthelmintic activity of Albendazole is thought to be primarily intra-intestinal. When a higher dose is given, a sufficient amount of Albendazole will be absorbed and can be used to treat hydatid disease and neurocysticercosis.
Albendazole is poorly absorbed from the gastrointestinal tract but rapidly undergoes extensive first-pass metabolism. The main/principal metabolite, albendazole sulfoxide, which is widely distributed in the body especially in the bile and the CSF, has anthelmintic activity and a plasma half-life of 8.5 hours. It is approximately 70% protein-bound to the plasma protein. It is then mainly eliminated in the bile while a small amount is excreted in the urine.

For the treatment of single or mixed intestinal helminthic infestations, including pinworm, whipworm, roundworm, hookworm, tapeworm, trichinosis and threadworm (strongyloides).

Chewable tab: For threadworm, whipworm, roundworm and hookworm infestation: Adults & children above 2 years: Chew 2 tablets as a single dose.
Children 1 to 2 years: Chew 1 tablet as a single dose.
For tapeworm and strongyloides infestation: Adults & children above 2 years: Chew 2 tablets once daily for 3 consecutive days.
Children 1 to 2 years: Chew 1 tablet once daily for 3 consecutive days.
Oral Susp: For infestation of pinworm, whipworm, roundworm, hookworm and trichinosis: Adults and children above 2 years: Take 10 ml as a single dose.
Children 1 to 2 years: Give 5 ml as a single dose.
For infestation of tapeworm and threadworm (strongyloides): Adults and children above 2 years: Take 10 ml once daily for 3 consecutive days.
Children 1 to 2 years: Give 5 ml once daily for 3 consecutive days.
To be taken with meal.
A second course may be repeated after 2 to 3 weeks if infestations persist or recur.
Always shake well before use.

Symptoms: Gastrointestinal symptoms may occur in Albendazole overdose such as nausea, vomiting, diarrhoea and abdominal pain.
Treatment: Gastric lavage may be performed in first 2 to 3 hours after ingestion and other supportive and symptomatic treatment may be carried out if necessary.

Patients with known hypersensitivity to Albendazole or other Benzimidazole derivatives. Albendazole is known to be teratogenic and embryotoxic in some animals. Therefore it should not be administered during pregnancy or in women thought to be pregnant.
Women of childbearing should take the medication within 7 days after the start of menstruation.

If symptoms/infestations persist or reoccur, consult a doctor.
Chewable tab: Unsuitable for phenylketonurics.
Oral susp: All family members and others in close contact should be treated at the same time to prevent reinfestations.
Not recommended for children under 1 year unless advised by a doctor.
Should not be administered during confirmed or suspected pregnancy.
Patients treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy to minimize cerebral hypertensive episodes.

Pregnancy: Chewable tab: Should not be administered during confirmed or suspected pregnancy.
Oral susp: Category C: Not recommended during confirmed or suspected pregnancy as the safety for use during pregnancy has not been established.
Lactation: Use with caution during lactation as extent of excretion in breast milk is not known.
Oral susp: Breast-feeding women should discuss this with their doctor before taking.

Albendazole is generally well tolerated.
Chewable tab: Symptoms reported include gastrointestinal symptoms and headache.
Oral susp: Some undesirable effects reported include abdominal pain, nausea, vomiting, diarrhoea and headache.

Caution should be taken when Albendazole is administered concurrently with these medications: Plasma concentration of the active metabolite of Albendazole is raised/increased when administered concomitantly with Dexamethasone, Praziquantel and Cimetidine.
Oral susp: Coadministration with Carbamazepine may decrease the efficacy of Albendazole.

Store below 30°C. Protect from light and moisture. Keep container tightly closed.
Shelf Life: 3 years from the date of manufacture.

Anthelmintics

P02CA03 - albendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.

NP