Noxworm Mechanism of Action

Pharmacology: Albendazole a broad-spectrum anthelmintic that exhibits vermicidal, ovicidal and larvacidal activities. Albendazole exerts its anthelmintic effect by inhibiting tubulin polymerization. This causes a cascade of metabolic disruption which includes energy depletion, immobilization and finally death. The anthelmintic activity of Albendazole is thought to be primarily intra-intestinal. When a higher dose is given, a sufficient amount of Albendazole will be absorbed and can be used to treat hydatid disease and neurocysticercosis.
Albendazole is poorly absorbed from the gastrointestinal tract but rapidly undergoes extensive first-pass metabolism. The main/principal metabolite, albendazole sulfoxide, which is widely distributed in the body especially in the bile and the CSF, has anthelmintic activity and a plasma half-life of 8.5 hours. It is approximately 70% protein-bound to the plasma protein. It is then mainly eliminated in the bile while a small amount is excreted in the urine.