Sign Out
Symptoms: Symptoms of orphenadrine overdosage are excitement, confusion, delirium leading to coma. Convulsions and tachycardia with dilated pupils and urinary retention may occur. Paracetamol overdosage may cause acute liver damage, but symptoms may not appear for up to several days after ingestion.
Treatment: Gastric lavage should be carried out immediately regardless of the estimated ingested dose. Convulsions and delirium respond to relatively large doses of diazepam, preferably by mouth. Adequate hydration of the patient is important. It is recommended that the patient be referred to a hospital where early and regular monitoring of plasma paracetamol levels can be carried out. If instituted sufficiently early, treatment with N-acetylcysteine, L-methionine or L-cysteamine will minimize liver damage.
