Nicardia-XL Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Nifedipine

Indications/Uses

CHD; chronic stable angina pectoris; HTN.

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Dosage/Direction for Use

1 tab once daily.

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Overdosage

View Nicardia-XL overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food: Swallow whole, do not chew/break tab. Avoid grapefruit juice.

Contraindications

Hypersensitivity. Not to be used in patients w/ CV shock, higher-grade aortic stenosis, unstable angina pectoris, acute MI w/in 1st 4 wk; severe hypotension (systolic BP <90 mmHg) or existing heart muscle weakness; acute angina attacks; secondary prevention of MI; history of GI or oesophageal obstruction or any degree of decreased lumen GI tract diameter; Kock pouch; inflammatory bowel disease or Crohn's disease. Concomitant use w/ rifampicin. Hepatic impairment.

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Special Precautions

Severe hypotension (systolic BP <90 mmHg); poor cardiac reserve; malignant HTN, hypovolaemia. Diabetic patients. Avoid grapefruit juice. Concomitant use w/ β-blockers, other antihypertensives, macrolides, anti-HIV PIs, azole antimycotics, nefazodone, fluoxetine, quinupristin/dalfopristin, valproic acid, cimetidine. May affect ability to drive or operate machinery. Hepatic impairment. Pregnancy & lactation. Childn & adolescents <18 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, flushing, heat sensation; oedema, vasodilatation; constipation; feeling unwell.

Drug Interactions

Reduced bioavailability & weakened efficacy w/ rifampicin. Increased exposure w/ macrolides, anti-HIV PIs, azole antimycotics, fluoxetine, nefazodone, quinupristin/dalfopristin, cisapride, valproic acid, cimetidine, diltiazem. Decreased exposure w/ rifampicin, phenytoin, carbamazeine, phenobarb. Increased BP-lowering effect of antihypertensives. Deterioration of heart failure w/ β-receptor blockers. Reduced digoxin clearance. Lowered plasma quinidine levels. Concomitant use w/ tacrolimus. Elevated plasma conc & prolonged action w/ grapefruit juice. Falsely increased spectrophotometric values of urinary vanillymandelic acid.

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Storage

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Description

View Nicardia-XL description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Calcium Antagonists / Anti-Anginal Drugs

ATC Classification

C08CA05 - nifedipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Nicardia-XL ER tab 30 mg

Packing/Price

3 × 10's

Nicardia-XL

nifedipine

Manufacturer:

Unique Pharma Lab

Distributor:

Unimed