GI perforations, haemorrhage, arterial thromboembolism. Febrile neutropenia, leucopenia, neutropenia, thrombocytopenia; anorexia, hypomagnesaemia, hyponatraemia; peripheral sensory neuropathy, dysgeusia, headache, dysarthria; eye disorder, increased lacrimation; HTN; dyspnoea, epistaxis, rhinitis, cough; GI disorders; ovarian failure; exfoliative dermatitis, dry skin, skin discolouration; arthralgia; proteinuria; asthenia, fatigue, pyrexia, pain, mucosal inflammation; decreased wt. Sepsis, abscess, cellulitis, infection; anaemia, lymphopenia; dehydration; CVA, syncope, somnolence; congestive cardiac failure, supraventicular tachycardia; arterial thrombolism, DVT, haemorrhage; pulmonary embolism, hypoxia; palmar-plantar erythrodysaesthesia syndrome; muscular weakness, myalgia, back pain; UTI; lethargy; pelvic pain.