Multico Overdosage

Symptoms of overdosage of vitamin A are similar to those of hypervitaminosis A mentioned under adverse reactions.
The treatment of hypervitaminosis A consists of immediate withdrawal of the vitamin along with symptomatic and supportive treatment. Most signs and symptoms disappear within a week, but hyperostoses remain evident for several months after clinical recovery has occurred.
Overdosage of vitamin D can cause hypercalcaemia, hypercalciuria and hyperphosphataemia Treatment of hypercalcaemia and overdosage: The treatment consists of immediate discontinuation of the vitamin. Serum calcium measurements should be performed regularly until normocalcemia ensues. Hypercalcaemia normally resolves in two to four weeks.
Treatment of accidental/acute overdosage: The treatment of acute accidental overdosage should consist of general supportive measures. If drug ingestion is discovered within a relatively short time, induction of emesis or gastric lavage may be of benefit in preventing further absorption. If the drug has passed through the stomach, the administration of mineral oil may promote faecal elimination. Serial serum calcium determination, rate of urinary calcium excretion and an assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Discontinuation of supplemental calcium and low calcium diet are also indicated in accidental overdosage. Should persistent and marked hypercalcemia occur, the use of drugs such as phosphates and corticosteroids as well as measures to induce an appropriate forced diuresis may be considered. The use of peritoneal dialysis against a calcium free dialysate may also be considered.
Adverse effects arising from overdosage is remote, as these are water-soluble vitamins, they are not stored to any significant extent in the body. Any excess are readily excreted.