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Immunosuppressive drugs, gemfibrozil, niacin (nicotinic acid), erythromycin and itraconazole.
When lovastatin and coumarin anticoagulants are administered concomitantly, prothrombin time may be increased in some patients. In patients taking anticoagulants, prothrombin time should be determined prior to starting therapy with lovastin and thereafter, monitored at the intervals usually recommended for patients on coumarin anticoagulants.
Myopathy or rhabdomyolysis has occurred in transplant and nontransplant patients receiving lovastatin following the initiation of treatment with the antifungal, itraconazole. This is probably related to metabolism of both drugs by the same P-450 isoform. Therapy with lovastatin should be temporarily interrupted if itraconazole therapy is required.
