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The patient should be placed on a standard cholesterol-lowering diet before receiving lovastatin and should continue on this diet during treatment with the drug. The usual starting dose is 20 mg/day given as a single dose with the evening meal. Adjustment of dosage, if required, should be made at intervals of not less than 4 weeks, to a maximum of 80 mg daily given in single doses or divided doses with morning and evening meals.
Concomitant Therapy: Preliminary evidence suggests that the cholesterol-lowering effects of lovastatin and the bile acid sequestrant, cholestyramine, are additive.
Patients with Renal Insufficiency: In patients with severe renal insufficiency (creatinine clearance <30 mL/min) dosage increases >20 mg/day should be carefully inserted and, if deemed necessary, implemented cautiously.
To be dispensed on physician's prescription.
