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Patients with severe liver impairment should be administered with a lower initial dose because they may have reduced clearance of Loratadine; an initial dose of 5 mg once daily or 10 mg every other day is recommended.
Use in Children: Efficacy of Loratadine in children less 2 years have not been established. However, the pharmacokinetic profile of Loratadine in infants 1 - 2 years after the administration of a single 2.5 mg dose of Loratadine syrup is similar to that in older children and adult.
