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Loratadine has no clinically significant sedative properties at the daily recommended dose of 10 mg. Most commonly reported dose of 10 mg.
Most commonly reported adverse effects include fatigue, headache, somnolence, dry mouth, gastrointestinal disorders, e.g. nausea, gastritis and also allergic symptoms, i.e. rash.
During the marketing of Loratadine tablet, alopecia, anaphylaxis and abnormal hepatic function have been reported rarely.
In controlled pediatric clinical trials, the incidence of treatment related headache, sedation and nervousness, which were rarely reported events, was similar to that of placebo.
