Lodoz Use In Pregnancy & Lactation

Pregnancy: Lodoz is not recommended during pregnancy.
Bisoprolol: Animal studies did not show any teratogenic effect. To date, results of well-controlled prospective studies with some beta-blockers did not show any birth defect in newborns. In neonates born from mothers treated with beta-blockers, beta-blocking activity persists for several days post-partum and may induce bradycardia, respiratory distress and hypoglycaemia. In most cases, this impregnation is without any clinical consequences. Nevertheless, heart failure may occur, necessitating intensive care unit management, avoiding plasma expanders (risk of acute pulmonary oedema).
Hydrochlorothiazide: Diuretics may give raise to foetoplacental ischemia with the attendant risk of foetal hypotrophy. Rare cases of severe neonate thrombocytopenia have been reported.
Lactation: It is not known if bisoprolol is excreted in human milk. Thiazide diuretics are excreted in human milk in minimal amounts. Thus, this medication should not be given to lactating women.
Bisoprolol: The risk for hypoglycaemia and bradycardia in suckling infant has not been evaluated.
Hydrochlorothiazide: Thiazide diuretics may produce: Decrease or even suppression of milk secretion; Adverse biological effects (hypokalemia); Hemolysis (G6PD defect) and hypersensitivity due to sulphonamide properties.
Fertility: No human data on fertility are known for the combination product.
Bisoprolol or hydrochlorothiazide had no influence on fertility or on general reproduction performance in animal studies.