Lodoz Dosage/Direction for Use

For individual therapy Lodoz is available in the strengths: Lodoz 2.5/6.25 mg, film-coated tablets; Lodoz 5/6.25 mg, film-coated tablets.
The initial dosage is one tablet containing bisoprolol 2.5 mg + hydrochlorothiazide 6.25 mg once daily.
If inadequate response to treatment is obtained, the dosage should be increased to one tablet containing bisoprolol 5 mg + hydrochlorothiazide 6.25 mg in a once daily dose. If latter proves to be insufficiently effective, the dosage may be increased to bisoprolol 10 mg + hydrochlorothiazide 6.25 mg once daily.
If discontinuation is necessary, gradual discontinuation of bisoprolol treatment is recommended, since abrupt withdrawal of bisoprolol may lead to an acute deterioration of the patient's condition, in particular in patients with ischaemic heart disease.
Lodoz should be swallowed in the morning and can be taken with food. The film-coated tablets should be swallowed with some liquid and not be chewed.
No dose adjustment is necessary in patients with mild-to-moderate hepatic impairment or mild-to-moderate renal impairment (creatinine clearance > 30 mL/min).
Elderly: No dose adjustment is normally required.
Paediatric population: Experience with Lodoz in paediatric patients is limited, therefore its use cannot be recommended in this population.
Route of Administration: Oral.