Lodoz Overdosage

The most common signs expected with overdose of a beta-blocker are bradycardia, hypotension, bronchospasm, acute cardiac insufficiency and hypoglycaemia. There is a wide inter-individual variation in sensitivity to one single high dose of bisoprolol and patients with heart failure are probably very sensitive.
The clinical picture in acute or chronic overdose of hydrochlorothiazide is characterised by the extent of fluid and electrolyte loss.
Most common signs are dizziness, nausea, somnolence, hypovolaemia, hypotension, hypokalaemia.
In general, if overdose occurs, discontinuation of Lodoz and supportive and symptomatic treatment is recommended.
Bradycardia: Administer intravenous atropine. If the response is inadequate, isoprenaline or another agent with positive chronotropic properties may be given cautiously. Under some circumstances, transvenous pacemaker insertion may be necessary.
Hypotension: intravenous fluids and vasopressors should be administered.
AV block (second or third degree): Patients should be carefully monitored and treated with isoprenaline infusion or intravenous cardiac pacemaker insertion.
Acute worsening of heart failure: Administer I.V. diuretics, inotropic agents, vasodilating agents.
Bronchospasm: Administer bronchodilator therapy such as isoprenaline, beta₂-sympathomimetic drugs and/or aminophylline.
Hypoglycaemia: administer I.V. glucose.
Limited data suggest that bisoprolol is hardly dialyzable. The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.