The following convention has been utilised for the classification of frequency of undesirable effects: very common ≥1/10 (≥10%), common ≥1/100 and < 1/10 (≥ 1% and <10%), uncommon ≥1/1000 and <1/100 (≥0.1% and <1%), rare ≥1/10,000 and <1/1000 (≥0.01% and <0.1%), very rare <1/10.000 (<0.01%). (See table.)
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Description of selected adverse reactions: Hepatobiliary disorders: The liver toxicity associated with vascular endothelial damage occurs at a frequency of very common when thioguanine is used in maintenance or similar long term continuous therapy which is not recommended (see Dosage & Administration and Precautions).
Rare: Centrilobular hepatic necrosis has been reported in a few cases including patients receiving combination chemotherapy, oral contraceptives, high dose thioguanine and alcohol.
Reversal of signs and symptoms of this liver toxicity has been reported upon withdrawal of short term or long term continuous therapy.
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