Not recommended for maintenance therapy or similar long-term continuous therapy due to high risk of hepatic toxicity w/ vascular endothelial damage. Bone marrow suppression leading to leucopoenia, thrombocytopenia. Patients w/ inherited deficiency of thiopurine methyltransferase enzyme & NUDT15 gene variant; Lesch-Nyhan syndrome. Asian patients. Monitor full blood cell counts & hepatic function tests wkly. Limit exposure to sun- & UV light. Not recommended w/ live vaccines. Avoid use during pregnancy & lactation.
Not recommended w/ live vaccines. Risk of myelosuppression w/ other myelotoxic substances or radiation therapy. Aminosalicylate derivatives eg, olsalazine, mesalazine or sulphasalazine.
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