Ketipinor Overdosage

Experience with quetiapine in overdosage is limited. Estimated doses of quetiapine up to 20 g have been taken, without fatal consequences. Patients recovered without sequelae. There have been very rare reports of overdose of quetiapine alone resulting in death or coma, or QT-interval prolongation.
In general, reported signs and symptoms were those resulting from an exaggeration of the drug’s known pharmacological effects, i.e., drowsiness and sedation, tachycardia and hypotension.
There is no specific antidote to quetiapine. In cases of severe signs, the possibility of multiple drug involvement should be considered, and intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system. Whilst the prevention of absorption in overdose has not been investigated, gastric lavage (after intubation, if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.
Close medical supervision and monitoring should be continued until the patient recovers.