Icunes Side Effects

Summary of the safety profile: The most frequently reported adverse reactions with dexmedetomidine are hypotension, hypertension and bradycardia.
List of adverse reactions: Metabolism and nutrition disorders: Common: Hyperglycaemia, hypoglycaemia.
Uncommon: Metabolic acidosis, hypoalbuminaemia.
Psychiatric disorders: Common: Agitation.
Uncommon: Hallucination.
Cardiac disorders: Very common: Bradycardia*.
Common: Myocardial ischaemia or infarction, tachycardia.
Uncommon: Atrioventricular block first degree, cardiac output decreased.
Vascular disorders:Very Common: Hypotension*, hypertension*.
Respiratory, thoracic and mediastinal disorders: Common: Respiratory depression.
Uncommon: Dyspnoea, apnoea.
Gastrointestinal disorders: Common: Nausea, vomiting, dry mouth.
Uncommon: Abdominal distension.
General disorders and administration site conditions: Common: Withdrawal syndrome, hyperthermia.
Uncommon: Drug ineffective, thirst.
* See Description of selected adverse reactions as follows.
Description of selected adverse reactions: Clinically significant hypotension or bradycardia should be treated as described in Precautions.
Bradycardia has occasionally led to sinus arrest or pause. The symptoms responded to leg raising and anticholinergics such as atropine or glycopyrrolate. In isolated cases, bradycardia has progressed to periods of asystole in patients with pre-existing bradycardia.
Hypertension has been associated with the use of a loading dose and this reaction can be reduced by avoiding such a loading dose or reducing the infusion rate or size of the loading dose.