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The most common adverse reactions reported in conjunction with overdose included bradycardia, hypotension, over sedation, somnolence and cardiac arrest.
In cases of overdose with clinical symptoms, dexmedetomidine infusion should be reduced or stopped. Expected effects are primarily cardiovascular and should be treated as clinically indicated. At high concentration, hypertension may be more prominent than hypotension. Cases of sinus arrest reversed spontaneously or responded to treatment with atropine and glycopyrrolate. Resuscitation was required in isolated cases of severe overdose resulting in cardiac arrest.
