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Live attenuated virus vaccines: Immunoglobulin administration may impair for a period of at least 6 weeks and up to 3 months the efficacy of live attenuated virus vaccines such as measles, rubella, mumps and varicella. After administration of this medicinal product, an interval of 3 months should elapse before vaccination with live attenuated virus vaccines. In the case of measles, this impairment may persist for up to 1 year.
Therefore, patients receiving measles vaccine should have their antibody status checked.
Interference with serological testing: After infusion of IgG, the transitory rise of the various passively transferred antibodies in patient's blood may lead to misinterpretation of the results of serological testing. Passive transmission of antibodies to erythrocyte antigens, e.g. A, B, D, may interfere with some serological tests for red cell alloantibodies (e.g. Coombs' test), reticulocyte counts and haptoglobin tests.
