Known hypersensitivity to the amlodipine, valsartan or to any of the excipients.
Pregnancy (see USE IN PREGNANCY & LACTATION).
Severe hepatic impairment; biliary cirrhosis and cholestasis.
Concomitant use of angiotensin receptor antagonists (ARBs) - including valsartan - or of angiotensin-converting enzyme inhibitors (ACEIs) with aliskiren in patients with Type 2 diabetes (see Dual blockade of the RAS under INTERACTIONS).