Discontinue immediately & not to be re-administered in patients w/ history of or angioedema. Not recommended as initial therapy in patients w/ intravascular vol depletion. Unilateral or bilateral renal artery stenosis, stenosis to solitary kidney; after recent kidney transplantation. Serious CHF (NYHA class III-IV), angina pectoris & acute MI; severe obstructive CAD; aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy. Correct Na &/or vol depletion prior to treatment. Monitor serum K, LFTs, renal function. Concomitant use w/ K supplements, K-sparing diuretics, K-containing salt substitutes, or other drugs increasing serum K (eg, heparin). Co-administration w/ renin-angiotensin system blockers eg, ACE inhibitors or aliskiren. Avoid concomitant use w/ aliskiren in patients w/ severe renal impairment. Mild to moderate hepatic impairment w/o cholestasis. Severe renal impairment (CrCl <10 mL/min) & dialysis. Not to be used in women of childbearing potential. Not to be used during pregnancy & lactation. Not recommended in childn <18 yr.