Enablex is contraindicated in patients with: Hypersensitivity to the active substance or to any of the excipients; Urinary retention; Gastric retention; Uncontrolled narrow-angle glaucoma; Myasthenia gravis; Severe hepatic impairment (Child Pugh C); Severe ulcerative colitis; Toxic megacolon; Concomitant treatment with potent CYP3A4 inhibitors (see INTERACTIONS).