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Pregnancy: The safety of DIPRIVAN during pregnancy has not been established. Studies in animals have shown reproductive toxicity (see Pharmacology: Toxicology: Pre-clinical Safety Data under Actions). Therefore DIPRIVAN should not be used in pregnancy unless clearly necessary.
DIPRIVAN has been used, however, during termination of pregnancy in the first trimester.
Obstetrics: DIPRIVAN crosses the placenta and may be associated with neonatal depression.
It should not be used for obstetric anaesthesia unless clearly necessary.
Lactation: Safety to the neonate has not been established following the use of DIPRIVAN in mothers who are breast-feeding.
